Most big wheel can have several antonyms depending on the context it is used in. In the context of leadership, antonyms for most big wheel can be a follower, a subordinate or an underling. Similarly, in the context of transportation, most big wheel can have antonyms such as a bicycle, a scooter, or a skateboard. In terms of personality traits or characteristics, antonyms for most big wheel can be humble, modest or meek. Ultimately, the antonyms for most big wheel will depend on the context of the sentence and the intended meaning.