The antonyms for the word "most nit-picking" are easy-going, laid-back, and relaxed. These words are used to describe people who are not overly concerned with minor details and are comfortable with a more casual approach to life. They tend to be more flexible and adaptable than those who are nit-picking. While attention to detail can be important in some situations, it can also lead to unnecessary stress and anxiety. Being easy-going and relaxed can often lead to a more enjoyable and less stressful experience, allowing individuals to focus on the bigger picture instead of getting bogged down in the details.