When it comes to finding synonyms for the word "acme's opposite", there are a few options to choose from. Firstly, one could use the word "nadir", which refers to the lowest point or bottom level of something. Another option could be "antithesis", which means the exact opposite or contrast of something. Additionally, "perigee" is another synonym that could be used, which refers to the point in the orbit of a celestial body when it is nearest to the earth. Overall, while there are a few different synonyms that could be used for the term "acme's opposite", each of these options paints a clear picture of something that is the complete opposite or lowest point of a given situation or circumstance.