Acquired agammaglobulinemia is a rare immune disorder that affects the body's ability to produce antibodies. Synonyms for this condition include late-onset hypogammaglobulinemia, immunoglobulin deficiency, and common variable immunodeficiency. The symptoms of acquired agammaglobulinemia can be similar to those seen in patients with other immune disorders, such as frequent infections or allergies. Treatment often involves regular infusions of immunoglobulin to replace the missing antibodies. While the cause of this condition is not entirely understood, it is thought to be related to genetic and environmental factors. Early diagnosis and treatment can help to manage the symptoms of acquired agammaglobulinemia and improve overall quality of life.