Adult Gangliosidosis GM is a rare genetic disorder that affects the nervous system. Synonyms for this condition include GM gangliosidosis or adult GM1 gangliosidosis. Adult Gangliosidosis GM is characterized by the buildup of harmful substances called gangliosides in the brain and other organs, leading to progressive neurologic deterioration. Symptoms may include muscle weakness, difficulty speaking and swallowing, loss of coordination, and cognitive decline. This condition is inherited in an autosomal recessive pattern, meaning that an affected individual must inherit two copies of the defective gene, one from each parent. Treatment is primarily supportive, focusing on managing symptoms and improving quality of life.