The phrase "all up with" is an idiom that denotes the end of something or a failure. There are several synonyms that can be used to replace this phrase based on the context in which it is used. Some of the alternative words include "finished," "over," "done for," "kaput," "ruined," "toast," "wrecked," "gone," "dead," and "through." These synonyms may be used interchangeably with "all up with" to describe a situation that has come to an end. It is essential to choose the right synonym based on the context of the sentence to convey the intended meaning accurately.