Amide hydrolysis is a chemical reaction where an amide bond is broken down by water, resulting in the formation of a carboxylic acid and an amine. There are several synonyms for this process, including amidolysis, amide cleavage, and amide splitting. Amidolysis describes the specific breakdown of an amide bond by a nucleophile, while amide cleavage and amide splitting are more general terms for the process of breaking down an amide bond. Other related terms include amide degradation and amide breakdown. Amide hydrolysis is an important process in organic chemistry and biochemistry, as it is involved in the metabolism of proteins and other amide-containing molecules.