Angiogenesis is the synonym for angiopoiesis, which refers to the process of new blood vessel formation. Other synonyms for angiopoiesis include neovascularization and vascular proliferation. Angiogenesis is an essential process for the growth of new tissues and wound healing. However, abnormal angiogenesis is implicated in various diseases, including cancer, inflammatory disorders, and diabetic retinopathy. Anti-angiogenesis therapy is a strategy that aims to prevent pathological angiogenesis and facilitate the treatment of diseases. Several factors, including hypoxia, inflammation, and growth factors, play critical roles in regulating angiogenesis. Thus, understanding the underlying mechanisms of angiogenesis may assist in the development of novel clinical interventions targeting this process.