Antsy-pantsy is a colloquial term to describe someone who is restless, agitated or fidgety. If you are looking for other synonyms to describe such a person, you could use the following alternative words and phrases: jittery, anxious, uneasy, nervous, hyperactive, restless, on edge, fidgety, twitchy, squirrelly, skittish, high-strung, overstimulated, wired, or keyed up. These words are suitable for describing someone who is overly energetic or unsettled. However, it is important to keep in mind the context since certain words may carry more negative connotations than others.