The antonyms for the phrase "are on and up" refer to a decline or decrease in circumstances, momentum, or success. These antonyms may include "are down and out," "are sluggish and stagnant," "are declining and deteriorating," or "are at a standstill." When things are "on and up," it often implies growth, improvement, and progress. Therefore, the opposite phrase denotes a lack of progress or even regression. These antonyms can refer to anything from the state of the economy to the state of an individual's mental health. It is essential to remember that in every life cycle, there are times when things are down, but with resilience and determination, one can always climb back up.