There are several antonyms for the phrase "art one's lot," which means to accept one's fate or circumstances. One such antonym is "resist," as it implies actively opposing or rejecting one's lot rather than accepting it. Another antonym could be "aspire," as it suggests looking towards a different future rather than being satisfied with the present. Additionally, "change" could be an antonym, as it signifies a desire to alter one's lot in life rather than accepting it. Lastly, "renounce" could be an antonym, as it means to give up or reject one's lot entirely.