The phrase "at wit's end" refers to a state of extreme confusion or frustration. The antonyms for this phrase include "with ease," "calmly," "comfortable," and "relaxed." If someone is feeling calm, comfortable, and relaxed, they are not at their wits' end. They are able to handle things confidently and without getting overwhelmed. Having peace of mind and mental clarity are critical to avoiding a sense of frustration and exhaustion. By maintaining a positive outlook, practicing self-care, and seeking support from others, one can avoid reaching their wits' end and instead experience peace, tranquility, and happiness in life.