The Battle of Issus was a major conflict between the forces of Alexander the Great and the Persians, which took place in 333 BC. There are numerous synonyms for the term "Battle of Issus" as it has been documented by different historians and chroniclers over the centuries. Some popular synonyms for the Battle of Issus include the Battle of Alexander and Darius, the Battle of Issos, the Battle of Issus River, and the Second Battle of Issus. These terms accurately depict the historical event and provide insight into the details and context of the battle, which remains one of the most significant military battles of all time.