The phrase "be up and about" is typically used to describe someone who is active and moving around. The antonyms for this phrase would be "sick", "incapacitated", "bedridden", "laid up", and "immobile". These words describe individuals who are unable to move freely due to illness, injury, or disability. When someone is not up and about, they are typically confined to a bed or a specific location, and are unable to perform daily tasks without assistance. It is important to note that while being up and about is generally seen as positive, there are times when rest and recovery are necessary to improve overall health and well-being.