There are a number of synonyms that can be used to replace the phrase "be-damned" in writing and speech. Some of the most common alternatives include "cursed," "condemned," "damnable," "doomed," "accursed," "fated," and "jinxed." Depending on the context, other possibilities might include terms like "hexed," "plagued," "stricken," "unlucky," "ill-fated," or "haunted." Each of these words carries a slightly different connotation and nuance, so it's important to choose the right synonym carefully based on the intended meaning and tone of the sentence or phrase in question.