Being on and up is often associated with positivity, happiness, and success. However, there are several antonyms that suggest the opposite. When you are not on and up, you may feel negative, unhappy, and unsuccessful. Some antonyms for being on and up include down, depressed, discouraged, disheartened, demoralized, and defeated. These words paint a picture of someone who is struggling to stay positive and keep their life on track. It's important to remember that everyone has ups and downs in life, but recognizing when you need help and seeking out support can make a world of difference.