The phrase "blow someone's brains out" is a violent and disturbing expression that refers to killing someone with a gunshot to the head. It is not an appropriate or acceptable phrase to use in polite conversation. Instead, there are a number of synonyms that can be used to convey a similar meaning without resorting to such graphic and disturbing language. These include "shoot someone dead," "take someone out," "put a bullet in someone," "kill someone with a gun," or "execute someone." While these phrases may still be unsettling, they are less graphic and more appropriate for use in everyday conversation.