Cape Girardeau is a city name that doesn't lend itself easily to synonyms. However, one might consider alternative descriptors such as "Cape" or "Girardeau" to refer to this place. Other potential synonyms might also be "Southeast Missouri" or "Mississippi River town," referencing the city's location in the state and its proximity to the waterway. Additionally, descriptions such as historic, charming, or quaint could apply to Cape Girardeau and capture aspects of its character and appeal. Regardless of the words used, this city is sure to offer visitors and residents alike a unique and memorable experience.