Cat's-eye syndrome is a rare medical condition that affects multiple systems of the body. The syndrome is also known as Schmid-Fraccaro syndrome and is caused by an abnormality in chromosome 22. People with this condition often have characteristic features such as small head size, wide-set eyes, and a small jaw. Individuals with Cat's-eye syndrome may also experience hearing loss, gastrointestinal problems, and heart defects. Some of the synonyms for Cat's-eye syndrome include Chromosome 22q11.2 deletion syndrome, DiGeorge syndrome, Shprintzen syndrome, and Velo-cardio-facial syndrome. Treatment for Cat's-eye syndrome is based on individual needs and may involve a team of medical professionals.