Cell fractionation is a widely used experimental technique in cell biology. It involves separating cell components from one another to better understand their functions and interactions within the cell. Synonyms for cell fractionation include cell fractioning, cell disruption, homogenization, and subcellular fractionation. These techniques are often employed to extract proteins, nucleic acids, and organelles from cells for further analysis. Other commonly used methods for cell fractionation include ultracentrifugation, electrophoresis, chromatography, and immunoprecipitation. With the advent of new technologies, such as single cell sequencing and proteomics, cell fractionation remains a fundamental tool for studying the complex world of cells and their biological functions.