Central nervous system fatigue is a condition characterized by a feeling of exhaustion and lethargy that arises due to prolonged periods of stress, overwork, or inadequate rest. Synonyms for central nervous system fatigue include mental exhaustion, burnout, fatigue, weariness, and lethargy. These terms all describe a state of physical and mental exhaustion that can be caused by various factors, such as lack of sleep, strenuous work, or emotional stress. Other terms that are sometimes used to describe central nervous system fatigue include brain fog, cognitive exhaustion, and mental fatigue. Regardless of the terminology used, central nervous system fatigue is a serious condition that can impact a person's overall health, wellbeing, and quality of life.