The phrase "Church of Rome" refers to the Roman Catholic Church, which is the largest Christian denomination in the world. There are several synonyms for this term, each with a specific connotation. One of the more common synonyms is the "Roman Church," which emphasizes the Church's strong connection to the city of Rome and its history. The term "Roman Catholic Church" is also often used interchangeably with "Church of Rome," as it clearly identifies the denomination and its beliefs. Additionally, the term "Holy See" can be used to refer to the leadership and administration of the Church, especially the position of the Pope as the head of the Church.