Classic Pelizaeus Merzbacher Disease (PMD) refers to a rare and inherited neurological disorder that primarily affects the central nervous system. It is characterized by the progressive degeneration of the myelin sheath, the protective covering around nerve fibers in the brain, leading to impaired transmission of electrical signals. Synonyms for PMD include classical PMD, familial PMD, and typical PMD. This condition predominantly affects males and is often associated with various signs and symptoms such as muscle weakness, coordination difficulties, and impaired cognitive development. It is crucial for individuals with PMD to receive timely diagnosis and multidisciplinary care to manage symptoms effectively and improve their quality of life.