Cloacal exstrophy is a rare congenital disorder characterized by a range of malformations affecting the abdominal and pelvic organs. There are no direct synonyms for this condition, but it may be referred to as cloacal anomaly, cloacal malformation, or persistent cloaca. Other related terms include congenital urogenital anomalies, urogenital malformations, and omphalocele-exstrophy-imperforate anus-spinal defects (OEIS) complex. Cloacal exstrophy can cause various physical and functional challenges, including bladder and bowel incontinence, infertility, and developmental delays. Treatment typically involves a multidisciplinary approach, including surgical intervention, medication management, and supportive care. Ongoing medical follow-up and support are essential for individuals and families affected by cloacal exstrophy.