Clonogenicity is defined as the ability of a single cell to give rise to a colony of cells. Synonyms for this term include colony formation capacity, clonality, clonal capacity, and clonogenicity potential. Other alternative words to describe this phenomenon are colony formation efficiency, proliferation potential, and stem cell self-renewal. These terms are often used interchangeably in scientific literature to describe the ability of cells to self-renew and differentiate into various cell types. The understanding of these processes is crucial in cancer research to determine the potential of tumor cells to grow and invade surrounding tissue, as well as in stem cell research to control differentiation and generate specific cell types for therapeutic applications.