Comparative Genomic Hybridization (CGH) is a specialized technique in genetics for identifying chromosomal aberrations and imbalances in DNA samples. There are various synonyms for the term, such as array-based comparative genomic hybridization (aCGH), comparative genomic microarray analysis (CGMA), chromosome microarray analysis (CMA), and molecular karyotyping. The technique is often used in cancer research, hereditary disease diagnosis, and prenatal testing. It allows researchers and healthcare professionals to map genomic variations and structural changes, thereby aiding in the diagnosis of genetic disorders. The development of CGH technology has revolutionized genetics research, enabling a more detailed understanding of how the genome works and how DNA alterations contribute to diseases.