Core biopsy is a medical procedure that involves taking a sample of tissue from a body part using a hollow needle. This technique is commonly used by doctors to diagnose conditions such as cancer and other abnormalities. There are a few synonyms for the term "core biopsy" including needle biopsy, percutaneous biopsy, and image-guided biopsy. Needle biopsy is a term that is used when a tiny needle is inserted into the area of suspicion to remove a small tissue sample. Percutaneous biopsy involves using a needle to access the tissue and can be done under local anesthesia. Image-guided biopsy uses imaging techniques such as ultrasound or CT scan to guide the biopsy needle to the appropriate area.