Deoptimize is a word that means to make something less efficient or effective. If you're looking for synonyms for the word deoptimize, there are several options that you can consider. One such synonym is the word suboptimal, which means less than ideal or not as good as it could be. Another word that you could use in place of deoptimize is the term downgrade, which means to reduce the status or rank of something. Other useful synonyms for deoptimize include the words impair, weaken, diminish, and lower, all of which convey the sense of making something less effective or efficient.