Deperdition is a rare and formal word that means loss or destruction. It is often used in legal or academic writing. Synonyms for this word include damage, ruin, waste, downfall, decline, degradation, collapse, and decay. These words imply a negative consequence or outcome and can be used to describe a variety of situations, from the inevitable decline of a business to the catastrophic destruction of a natural disaster. Deperdition can also refer to the moral decay of an individual or society. In this case, synonyms could include corruption, degradation, or depravity. The use of synonyms can help to add variety and nuance to your writing, while also ensuring that your meaning is clear and precise.