Depletory is a word that means causing depletion or reduction in quantity, force or power. Some synonyms for this word include exhausting, draining, consuming, diminishing, depleting, reducing, sapping and weakening. These words all convey the idea of something gradually wearing away or using up a resource, such as energy, resources or supplies. Depletory can also refer to something that is detrimental or harmful, so some additional synonyms might include harmful, detrimental, damaging, injurious and destructive. Ultimately, these words all describe the impact of something that has a negative effect on its surroundings.