Deubiquitination is the process that involves the removal of ubiquitin from a protein. This process is essential for the regulation of cellular processes such as protein degradation, protein trafficking, and signal transduction. There are several synonyms for deubiquitination, including debubbling, deubiquitinating, and deubiquitination cleavage. Others include de-ubiquitinating, de-polyubiquitinating, and peptide-specific proteolysis. These synonyms are used interchangeably in scientific literature and research studies. The importance of deubiquitination in cell biology has led to the development of numerous techniques and tools aimed at studying this process. Researchers continue to explore the complex mechanisms underlying deubiquitination and its implications in various pathological conditions.