Di Guglielmo disease, also known as acute erythroid leukemia, is a rare type of blood cancer that primarily affects the production of red blood cells. Despite its rarity, understanding different synonyms can be beneficial in medical research and communication. The synonyms for Di Guglielmo disease often used by medical professionals include erythroleukemia, Di Guglielmo's syndrome, acute myeloblastic leukemia with maturation, and M6 leukemia. These terms aid in the accurate classification and diagnosis of the disease, enabling effective communication between healthcare professionals. Recognizing these synonyms is crucial for medical practitioners, researchers, and patients alike, ensuring a comprehensive understanding of this specific type of leukemia, and enabling better treatment options and support.