DIHS stands for Drug-Induced Hypersensitivity Syndrome, which is a severe adverse reaction to particular medications. Synonyms for DIHS can include drug hypersensitivity, drug allergic reaction, drug rash with eosinophilia and systemic symptoms (DRESS), and drug-induced lymphocyte stimulation syndrome (DI-LSS). These terms may vary depending on the severity and specific symptoms of the condition. DIHS can result in severe skin reactions, fever, and organ failure, which can be life-threatening. It is essential to recognize the symptoms quickly and seek immediate medical attention. Sometimes, a change in medication can alleviate the symptoms, and treatment may include symptomatic relief until the condition subsides.