Disseminated neurodermatitis is a chronic skin condition characterized by thick, scaly patches of skin that itch incessantly. There are a few synonyms for this condition that can be used interchangeably: lichen simplex chronicus, prurigo chronica, and neurodermatitis circumscripta. Lichen simplex chronicus is the most commonly used term and refers to the thickening and hardening of the skin resulting from repeated scratching or rubbing. Prurigo chronica, on the other hand, describes the itching and scratching resulting from neurodermatitis. Neurodermatitis circumscripta focuses on the localized and circumscribed nature of the condition. Regardless of the wording used, treatment for this condition often involves a combination of medication, topical treatment, and lifestyle changes such as stress reduction to manage the itching and discomfort.