DNA-polynucleotide ligase is a term often used in molecular biology to refer to the enzyme that facilitates the joining of DNA strands. There are several synonyms for this term, including DNA ligase, polynucleotide ligase, and DNA sealing enzyme. DNA ligase is a commonly used term and refers to the enzyme's ability to ligate or join two DNA fragments together. Similarly, the term polynucleotide ligase emphasizes the enzyme's ability to link together multiple nucleotides. Finally, the term DNA sealing enzyme refers to the enzyme's role in sealing the nick or break in a DNA strand. Regardless of the term used, DNA-polynucleotide ligase plays a critical role in DNA synthesis and repair.