Down syndrome is a genetic condition that affects 1 in every 700 babies born in the United States. The condition is characterized by a variety of physical and intellectual disabilities, including low muscle tone, developmental delays, and cognitive impairment. However, using the term "Down syndrome" can sometimes carry negative connotations, emphasizing the negative aspects of the condition rather than the person as a whole. Some people prefer to use more neutral or positive terminology, such as "Trisomy 21", "Up syndrome", or "genetic difference". Using inclusive language is important to help reduce stigma and discrimination against those with Down syndrome.