Downers are a commonly used slang term for depressants or tranquilizers, which are drugs that slow down the central nervous system. Some synonyms for this term include sedatives, calmatives, relaxants, and tranquilizers. Other words that can be used to describe these drugs include depressants, anxiolytics, sleep aids, and anti-anxiety medications. While these substances can be helpful in treating medical conditions such as anxiety and insomnia, they can also be highly addictive and potentially dangerous if misused. It is important to always use prescription medications as directed by a healthcare professional and to avoid using them for non-medical purposes.