There are numerous ways to describe the activity of operating a truck on the road. Synonyms for "drive a truck" include "operate a truck," "maneuver a truck," "pilot a truck," or "steer a truck." Other options may include "navigate a truck," "control a truck," "command a truck," "guide a truck," or "handle a truck." Additionally, terms such as "drive a semi," "drive a big rig," or "drive a lorry" have region-specific usage. In essence, the term used to describe the activity of driving a truck can vary depending on the context, location and industry.