The phrase "effect of use" can be replaced by several synonyms that reflect its underlying meaning. Some of these synonyms include impact, consequence, outcome, result, influence, and efficacy. Each of these words conveys a different nuance in terms of the nature and extent of the effect that occurs as a result of using something. For instance, "impact" typically implies a strong and significant effect, while "outcome" refers to the final result of a process or action. Similarly, "influence" suggests that the effect is more indirect or subtle, while "efficacy" focuses on the effectiveness or ability of something to produce a desired outcome. By using synonyms for "effect of use," writers can vary their language and create a more nuanced and expressive style.