The Electrophoretic Mobility Shift Assay (EMSA) is a common laboratory technique used to detect protein-DNA interactions. However, there are several synonyms that can be used to describe this assay, such as gel-shift assay, band-shift assay, or DNA-protein binding assay. These terms all refer to the same technique that involves running a protein-DNA sample through a gel matrix. The protein-DNA complex will move slower and appear as a distinct band, while unbound DNA will move faster, resulting in a shifted band pattern. This powerful technique has numerous applications, including the characterization of transcriptional factors, the identification of binding sites, and the detection of mutations or polymorphisms within DNA sequences.