Epithelialization is the process of cells forming a layer of tissue on a wound to help facilitate healing. There are several synonyms that can be used to describe this process, including, but not limited to, re-epithelialization, wound closure, granulation, and tissue regeneration. Re-epithelialization specifically refers to the growth of new epithelial cells over the wound, and is often used in reference to skin injuries. Wound closure is a more general term that can refer to any process by which a wound is closed up, including epithelialization. Granulation refers to the growth of new connective tissue within a wound, while tissue regeneration refers to the generation of new cells and tissue to replace damaged or lost tissue.