FIME, which stands for First-In-Man Evaluation, is a term used in medical and pharmaceutical fields to describe the initial testing of a new drug or medical device in human patients. Some synonyms for FIME include clinical feasibility studies, human clinical trials, phase 1 studies, and early-stage clinical development. These studies are crucial in determining the safety and efficacy of a new product before it can be approved for widespread use. The results of FIME studies can also inform further clinical trials and help guide the development of future drugs and medical devices. Effective FIME studies are essential for ensuring the safety and well-being of patients, and for advancing medical science as a whole.