First-line treatment refers to the initial course of treatment that a patient receives for a particular medical condition. There are several synonyms for first-line treatment that describe the same concept, including primary treatment, initial therapy, frontline therapy, and primary therapy. Each of these phrases indicates the treatment that is prescribed first, before more aggressive interventions are tried. First-line treatment is typically prescribed based on the patient's diagnosis and medical history, and it is designed to provide relief from symptoms or cure the underlying condition. These synonyms for first-line treatment are often used interchangeably by medical professionals, and they all refer to the first course of treatment a patient receives.