Fissure of Rolando, also known as central sulcus, is an anatomical landmark in the brain that separates the frontal lobe from the parietal lobe. There are several synonyms used to refer to the Fissure of Rolando, depending on the discipline or field of study. In neuroanatomy, it is also called the Rolandic fissure, whereas in neuroimaging, it is termed the precentral sulcus or precentral gyrus. In some medical textbooks, it is also referred to as the lateral sulcus or Sylvian fissure. Regardless of the name, the Fissure of Rolando is a critical structure in the human brain, playing a significant role in motor and sensory function.