"Flying blister" is a rather unconventional term, but it can be interpreted as a metaphorical expression for something that is causing irritation or annoyance. When seeking synonyms to convey a similar meaning, one could use phrases like "irritating nuisance", "bothersome pest" or "annoying troublemaker". Additionally, words such as "perturbing irritant", "exasperating thorn" or "vexing source" might also serve as suitable alternatives. The key is to select words that capture the essence of the annoying or irksome nature implied in the phrase "flying blister", allowing for a more diverse and varied range of expressions in writing.