A gain-of-function mutation is a genetic alteration that enhances the function of a protein or enzyme, resulting in increased activity, stability, or expression level. Synonyms for gain-of-function mutations include activating mutations, enhancing mutations, and hypermorphic mutations. These mutations can lead to novel or increased protein activity, altered signaling pathways, and modified cell behavior, potentially leading to disease development or increased resistance to therapies. Understanding the mechanisms and consequences of gain-of-function mutations is crucial in developing targeted therapies and preventing the spread of diseases caused by these mutations. Studying alternative terms for gain-of-function mutations can help researchers improve their understanding and expand their vocabulary in the field of genetic research.