General lymphadenomatosis of bones is a rare condition characterized by the abnormal enlargement of lymph nodes within the skeletal framework. Synonymous terms for this condition include lymphoproliferative disease of bones, systemic lymphadenomatosis of bones, and lymphomatous bone infiltration. These synonyms are used interchangeably within medical literature and discussions to refer to the same ailment. The condition is typically associated with lymphoma, a type of cancer that originates in the lymphatic system. Common symptoms include bone pain, fractures, and generalized swelling in lymph nodes. Timely diagnosis and treatment are crucial in managing this condition effectively and improving long-term prognosis.