The Genus Hydrastis, commonly known as Goldenseal, is a medicinal plant native to North America. In herbal medicine, various synonyms for the Genus Hydrastis can be found, including Orange-root, Yellow puccoon, and Warnera. The plant's roots and rhizomes contain alkaloids that possess antimicrobial, anti-inflammatory, and astringent properties, making it a popular ingredient in natural remedies for various health conditions like respiratory tract infections, digestive problems, and skin irritations. Despite its therapeutic benefits, the Genus Hydrastis is listed as a threatened species due to its overexploitation in the wild. Therefore, utilizing synthetic substitutes or cultivating the plant sustainably is advocated to protect and preserve its medicinal value for the future.