Gierke Disease, also known as glycogen storage disease type I (GSDI), is a rare metabolic disorder characterized by the body's inability to break down glycogen properly. This condition primarily affects the liver, causing an abnormal accumulation of glycogen, leading to various complications. Despite its rare occurrence, it is crucial to understand the synonyms associated with Gierke Disease. Some common alternative terms used include glycogen storage disease type I, Von Gierke disease, GSDI, hepatorenal glycogenosis, or simply Von Gierke syndrome. Using these synonyms can help improve communication and understanding between healthcare professionals, patients, and their families regarding this specific condition and its management.