The antonyms for the phrase "give a break" would include terms such as "press on," "continue," "persist," "persevere," "endure," or "keep going." All of these words imply a sense of determination and steadfastness, indicating that no rest or leniency is to be given. Other antonyms may include phrases such as "refuse to budge" or "dig in," indicating a refusal to relent or compromise in any way. Overall, the antonyms for "give a break" are those that suggest a drive to push forward regardless of obstacles or the need for rest, indicating a steadfast and unrelenting pursuit of one's goals.